| Reaction Details |
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 | Report a problem with these data |
| Target | Glyceraldehyde-3-phosphate dehydrogenase |
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| Ligand | BDBM50100465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72892 (CHEMBL684059) |
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| IC50 | 14000±n/a nM |
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| Citation |  Bressi, JC; Verlinde, CL; Aronov, AM; Shaw, ML; Shin, SS; Nguyen, LN; Suresh, S; Buckner, FS; Van Voorhis, WC; Kuntz, ID; Hol, WG; Gelb, MH Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem44:2080-93 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glyceraldehyde-3-phosphate dehydrogenase |
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| Name: | Glyceraldehyde-3-phosphate dehydrogenase |
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| Synonyms: | G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36060.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1511315 |
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| Residue: | 335 |
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| Sequence: | MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
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| BDBM50100465 |
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| n/a |
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| Name | BDBM50100465 |
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| Synonyms: | 3,5-Dihydroxy-N-(4-hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-1-ylmethyl)-amino]-9H-purin-3-ylmethyl}-tetrahydro-furan-3-yl)-N-methyl-benzamide | CHEMBL303730 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N6O6 |
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| Mol. Mass. | 542.5426 |
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| SMILES | OC[C@H]1O[C@H]([C@H](NC(=O)c2cc(O)cc(O)c2)[C@@H]1O)n1cnc2c(NCc3cccc4ccccc34)ncnc12 |
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| Structure | 
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