| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50102477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106478 (CHEMBL719147) |
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| IC50 | 3.5±n/a nM |
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| Citation |  Pikul, S; Ohler, NE; Ciszewski, G; Laufersweiler, MC; Almstead, NG; De, B; Natchus, MG; Hsieh, LC; Janusz, MJ; Peng, SX; Branch, TM; King, SL; Taiwo, YO; Mieling, GE Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases. J Med Chem44:2499-502 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50102477 |
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| n/a |
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| Name | BDBM50102477 |
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| Synonyms: | 4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-methyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester | CHEMBL311266 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N2O8S |
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| Mol. Mass. | 506.569 |
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| SMILES | COCCOC(=O)N1CCC(CC1)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O |
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| Structure | 
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