Ki Summary

Reaction Details

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Target

M-phase inducer phosphatase 1

Ligand

BDBM50097534

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_49008 (CHEMBL662888)

IC50

5100±n/a nM

Citation

Peng, H; Xie, W; Otterness, DM; Cogswell, JP; McConnell, RT; Carter, HL; Powis, G; Abraham, RT; Zalkow, LH Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem44:834-48 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

M-phase inducer phosphatase 1

Name:

M-phase inducer phosphatase 1

Synonyms:

Type:

Protein

Mol. Mass.:

59090.18

Organism:

Homo sapiens (Human)

Description:

P30304

Residue:

524

Sequence:

MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

BDBM50097534

n/a

Name

BDBM50097534

Synonyms:

5-[3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-8-oxo-dodecahydro-7-oxa-cyclopenta[a]naphthalen-6-yl]-pentanoic acid | CHEMBL354296

Type

Small organic molecule

Emp. Form.

C27H46O4

Mol. Mass.

434.6517

SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC(=O)O[C@](C)(CCCCC(O)=O)[C@H]3CC[C@]12C

Structure