Ki Summary

Reaction Details

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Target

M-phase inducer phosphatase 1

Ligand

BDBM50097543

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_49008 (CHEMBL662888)

IC50

9300±n/a nM

Citation

Peng, H; Xie, W; Otterness, DM; Cogswell, JP; McConnell, RT; Carter, HL; Powis, G; Abraham, RT; Zalkow, LH Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. J Med Chem44:834-48 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

M-phase inducer phosphatase 1

Name:

M-phase inducer phosphatase 1

Synonyms:

Type:

Protein

Mol. Mass.:

59090.18

Organism:

Homo sapiens (Human)

Description:

P30304

Residue:

524

Sequence:

MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

BDBM50097543

n/a

Name

BDBM50097543

Synonyms:

CHEMBL165813 | [5-(4-Acetoxy-1-methyl-2-oxo-cyclohexyl)-1-(1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-acetic acid

Type

Small organic molecule

Emp. Form.

C29H48O5

Mol. Mass.

476.6884

SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H](CC(O)=O)[C@H](CC[C@]12C)[C@@]1(C)CCC(CC1=O)OC(C)=O

Structure