Reaction Details |
| Report a problem with these data |
Target | Chymotrypsin-C |
---|
Ligand | BDBM50098886 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_49619 (CHEMBL660458) |
---|
Ki | 177±n/a nM |
---|
Citation | Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Eda, M; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. J Med Chem44:1297-304 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Chymotrypsin-C |
---|
Name: | Chymotrypsin-C |
Synonyms: | CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C |
Type: | Enzyme |
Mol. Mass.: | 29487.98 |
Organism: | Homo sapiens (Human) |
Description: | Q99895 |
Residue: | 268 |
Sequence: | MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG
GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRN
DIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPV
VDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSR
RGCNTRKKPVVYTRVSAYIDWINEKMQL
|
|
|
BDBM50098886 |
---|
n/a |
---|
Name | BDBM50098886 |
Synonyms: | 4-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetylamino]-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid benzylamide | CHEMBL284017 |
Type | Small organic molecule |
Emp. Form. | C30H27F2N5O4 |
Mol. Mass. | 559.5633 |
SMILES | Nc1cnc(-c2ccccc2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O |
Structure |
|