| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
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| Ligand | BDBM50114078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106832 (CHEMBL717673) |
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| Ki | 5.9±n/a nM |
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| Citation |  Kavarana, MJ; Trivedi, D; Cai, M; Ying, J; Hammer, M; Cabello, C; Grieco, P; Han, G; Hruby, VJ Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem45:2644-50 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 3 |
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| Name: | Melanocortin receptor 3 |
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| Synonyms: | MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36044.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41968 |
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| Residue: | 323 |
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| Sequence: | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI
LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF
DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI
VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFREILCGCNGMNLG
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| BDBM50114078 |
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| n/a |
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| Name | BDBM50114078 |
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| Synonyms: | 8-(3-Guanidino-propyl)-2-(3H-imidazol-4-ylmethyl)-11-(1H-indol-3-ylmethyl)-5-naphthalen-2-ylmethyl-3,6,9,12,20,24-hexaoxo-1,4,7,10,13,19hexaaza-cyclotetracosane-14-carboxylic acid amide | CHEMBL313279 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H59N13O7 |
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| Mol. Mass. | 918.0543 |
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| SMILES | NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O |
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| Structure | 
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