Reaction Details |
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Target | Sodium/hydrogen exchanger 1 |
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Ligand | BDBM50058759 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_141044 (CHEMBL746892) |
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IC50 | 75±n/a nM |
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Citation | Fukumoto, S; Imamiya, E; Kusumoto, K; Fujiwara, S; Watanabe, T; Shiraishi, M Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives. J Med Chem45:3009-21 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/hydrogen exchanger 1 |
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Name: | Sodium/hydrogen exchanger 1 |
Synonyms: | NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 91655.00 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_862370 |
Residue: | 820 |
Sequence: | MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGD
VTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMK
IGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYF
LPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISA
VDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFL
SFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMAL
IASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVIS
TLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPM
CDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIED
ICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGK
IPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVA
DPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPV
ITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTD
DVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
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BDBM50058759 |
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n/a |
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Name | BDBM50058759 |
Synonyms: | CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine (Cariporide) | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine(Cariporide) | N-(4-isopropyl-3-methanesulfonyl-benzoyl)-guanidine | N-(diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C12H17N3O3S |
Mol. Mass. | 283.347 |
SMILES | CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)NC(N)=N |
Structure |
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