| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50108688 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2290 |
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| Ki | 0.36±n/a nM |
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| Citation |  Fletcher SR; Burkamp F; Blurton P; Cheng SK; Clarkson R; O'Connor D; Spinks D; Tudge M; van Niel MB; Patel S; Chapman K; Marwood R; Shepheard S; Bentley G; Cook GP; Bristow LJ; Castro JL; Hutson PH; MacLeod AM 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem 45:492-503 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | Dopamine D2 receptor and serotonin 2a receptor |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2 | HTR2A | Serotonin receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52607.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 471 |
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| Sequence: | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
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| BDBM50108688 |
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| n/a |
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| Name | BDBM50108688 |
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| Synonyms: | 1-(4-fluorophenyl)-4-[6-methoxyspiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)]-1-yl]-1-butanone | CHEMBL357807 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28FNO3 |
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| Mol. Mass. | 397.4824 |
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| SMILES | COc1ccc2OC3(CCN(CCCC(=O)c4ccc(F)cc4)CC3)CCc2c1 |
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| Structure | 
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