| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Ligand | BDBM50118831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_123995 (CHEMBL734023) |
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| IC50 | >30000±n/a nM |
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| Citation |  Matsuno, K; Nakajima, T; Ichimura, M; Giese, NA; Yu, JC; Lokker, NA; Ushiki, J; Ide, S; Oda, S; Nomoto, Y Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. J Med Chem45:4513-23 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 6 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 6 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3 |
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| Type: | Protein |
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| Mol. Mass.: | 37494.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52564 |
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| Residue: | 334 |
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| Sequence: | MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
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| BDBM50118831 |
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| n/a |
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| Name | BDBM50118831 |
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| Synonyms: | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid benzylamide | CHEMBL319894 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N5O2S |
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| Mol. Mass. | 423.531 |
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| SMILES | COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC |
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| Structure | 
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