Ki Summary

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Target

Delta-type opioid receptor

Ligand

BDBM50122536

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_145336 (CHEMBL750571)

IC50

5300±n/a nM

Citation

Hanessian, S; Parthasarathy, S; Mauduit, M; Payza, K The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem46:34-48 (2002) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Delta-type opioid receptor

Name:

Delta-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40382.98

Organism:

Homo sapiens (Human)

Description:

Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.

Residue:

372

Sequence:

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA

BDBM50122536

n/a

Name

BDBM50122536

Synonyms:

4N,13N-di(4-bromobenzyl)-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene-4,13-diamine

Type

Small organic molecule

Emp. Form.

C33H33Br2N3

Mol. Mass.

631.443

SMILES

Brc1ccc(CNc2ccc3C[C@H]4[C@@H]5CCC(C=C5[C@@H]([C@@H]5CCCN45)c3c2)=NCc2ccc(Br)cc2)cc1 |w:27.32,wU:12.25,19.19,13.18,20.26,c:17,TLB:14:13:24.20:25.10.11,26:25:24.20:18.13,THB:21:20:18.13:25.10.11,23:24:18.13:25.10.11,9:10:24.20:18.13,(-1.25,-5.22,;.08,-5.99,;.08,-7.55,;1.41,-8.31,;2.74,-7.54,;4.08,-8.31,;4.08,-9.87,;5.42,-10.64,;5.42,-12.19,;6.77,-12.96,;8.1,-12.19,;9.43,-12.96,;10.97,-12.96,;10.76,-9.08,;12.1,-8.31,;12.1,-6.77,;10.76,-5.99,;9.43,-6.77,;9.43,-8.31,;9.43,-9.87,;13.62,-11.44,;14.9,-12.28,;14.5,-13.77,;12.98,-13.85,;12.42,-12.4,;8.1,-10.64,;6.77,-9.87,;10.76,-4.45,;12.09,-3.68,;12.09,-2.14,;13.43,-1.36,;13.43,.18,;12.1,.95,;12.1,2.49,;10.76,.16,;10.76,-1.36,;2.74,-6.01,;1.41,-5.24,)|

Structure