Ki Summary

Reaction Details

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Target

Mu-type opioid receptor

Ligand

BDBM50122530

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_145593 (CHEMBL749738)

IC50

690±n/a nM

Citation

Hanessian, S; Parthasarathy, S; Mauduit, M; Payza, K The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem46:34-48 (2002) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mu-type opioid receptor

Name:

Mu-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

44789.51

Organism:

Homo sapiens (Human)

Description:

P35372

Residue:

400

Sequence:

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

BDBM50122530

n/a

Name

BDBM50122530

Synonyms:

4-[16,17-dimethyl-13-(1,4-oxazinan-4-yl)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-4-yl]-1,4-oxazinane

Type

Small organic molecule

Emp. Form.

C26H35N3O2

Mol. Mass.

421.575

SMILES

C[C@@H]1[C@@H]2C3=CC(=CC[C@H]3[C@H](Cc3ccc(cc23)N2CCOCC2)N1C)N1CCOCC1 |wU:2.2,9.26,8.8,1.0,c:5,t:3,TLB:0:1:3.8:16.11.10,15:16:23.1:3.8,THB:12:11:23.1:3.8,7:8:23.1:16.11.10,24:23:3.8:16.11.10,(11.11,-4.34,;10.03,-5.44,;6.19,-4.18,;6.19,-2.62,;6.19,-1.08,;7.52,-.31,;8.87,-1.08,;8.87,-2.62,;7.52,-3.39,;7.75,-7.26,;6.19,-7.26,;4.86,-6.49,;3.53,-7.26,;2.2,-6.49,;2.2,-4.95,;3.53,-4.18,;4.86,-4.95,;.87,-4.18,;.87,-2.64,;-.46,-1.87,;-1.8,-2.62,;-1.81,-4.16,;-.47,-4.95,;9.18,-6.7,;10.13,-7.91,;7.52,1.23,;8.87,2,;8.87,3.54,;7.54,4.31,;6.19,3.54,;6.19,2,)|

Structure