| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50130700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195660 (CHEMBL800044) |
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| IC50 | 650±n/a nM |
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| Citation |  Choi, Y; George, C; Comin, MJ; Barchi, JJ; Kim, HS; Jacobson, KA; Balzarini, J; Mitsuya, H; Boyer, PL; Hughes, SH; Marquez, VE A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude. J Med Chem46:3292-9 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50130700 |
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| n/a |
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| Name | BDBM50130700 |
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| Synonyms: | 1-(5-Hydroxymethyl-bicyclo[3.1.0]hex-3-en-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; triphosphate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13N2O12P3 |
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| Mol. Mass. | 470.1613 |
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| SMILES | Cc1cn(C2C=C[C@]3(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C[C@H]23)c(=O)[nH]c1=O |c:5| |
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| Structure | 
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