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Compile Data Set for Download or QSAR

Found 120 hits with Last Name = 'boyer' and Initial = 'pl'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Integrase


(Human immunodeficiency virus 1)		BDBM50020284
PNG
(CHEMBL3288833)
Show SMILES COC(=O)[C@H](Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H20F2N4O5/c1-36-25(34)20(14-6-3-2-4-7-14)30-21-17-8-5-11-28-22(17)31(35)24(33)19(21)23(32)29-13-15-9-10-16(26)12-18(15)27/h2-12,20,30,35H,13H2,1H3,(H,29,32)/t20-/m1/s1
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n/an/a 8.20n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020294
PNG
(CHEMBL3288834)
Show SMILES COC(=O)[C@H](CO)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O6/c1-32-20(30)14(9-27)25-16-12-3-2-6-23-17(12)26(31)19(29)15(16)18(28)24-8-10-4-5-11(21)7-13(10)22/h2-7,14,25,27,31H,8-9H2,1H3,(H,24,28)/t14-/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020278
PNG
(CHEMBL3288827)
Show SMILES OCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C18H16F2N4O4/c19-11-4-3-10(13(20)8-11)9-23-17(26)14-15(21-6-7-25)12-2-1-5-22-16(12)24(28)18(14)27/h1-5,8,21,25,28H,6-7,9H2,(H,23,26)
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n/an/a 10n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020283
PNG
(CHEMBL3288832)
Show SMILES COC(=O)[C@@H](Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H20F2N4O5/c1-36-25(34)20(14-6-3-2-4-7-14)30-21-17-8-5-11-28-22(17)31(35)24(33)19(21)23(32)29-13-15-9-10-16(26)12-18(15)27/h2-12,20,30,35H,13H2,1H3,(H,29,32)/t20-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020307
PNG
(CHEMBL3288835)
Show SMILES COC(=O)[C@@H](CO)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O6/c1-32-20(30)14(9-27)25-16-12-3-2-6-23-17(12)26(31)19(29)15(16)18(28)24-8-10-4-5-11(21)7-13(10)22/h2-7,14,25,27,31H,8-9H2,1H3,(H,24,28)/t14-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020276
PNG
(CHEMBL3288825)
Show SMILES CC(C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C19H18F2N4O3/c1-10(2)24-16-13-4-3-7-22-17(13)25(28)19(27)15(16)18(26)23-9-11-5-6-12(20)8-14(11)21/h3-8,10,24,28H,9H2,1-2H3,(H,23,26)
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n/an/a 16n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020281
PNG
(CHEMBL3288830)
Show SMILES COC(=O)[C@H](C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O5/c1-10(20(29)31-2)25-16-13-4-3-7-23-17(13)26(30)19(28)15(16)18(27)24-9-11-5-6-12(21)8-14(11)22/h3-8,10,25,30H,9H2,1-2H3,(H,24,27)/t10-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020259
PNG
(CHEMBL3288817)
Show SMILES On1c2ncccc2c(Nc2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C22H16F2N4O3/c23-14-9-8-13(17(24)11-14)12-26-21(29)18-19(27-15-5-2-1-3-6-15)16-7-4-10-25-20(16)28(31)22(18)30/h1-11,27,31H,12H2,(H,26,29)
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n/an/a 18n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020309
PNG
(CHEMBL3288837)
Show SMILES Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C16H12F2N4O3/c17-9-4-3-8(11(18)6-9)7-21-15(23)12-13(19)10-2-1-5-20-14(10)22(25)16(12)24/h1-6,25H,7,19H2,(H,21,23)
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n/an/a 19n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020280
PNG
(CHEMBL3288829)
Show SMILES COC(=O)CNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C19H16F2N4O5/c1-30-14(26)9-23-16-12-3-2-6-22-17(12)25(29)19(28)15(16)18(27)24-8-10-4-5-11(20)7-13(10)21/h2-7,23,29H,8-9H2,1H3,(H,24,27)
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n/an/a 21n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020267
PNG
(CHEMBL3288824)
Show SMILES CCCCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C21H22F2N4O3/c1-2-3-4-9-24-18-15-6-5-10-25-19(15)27(30)21(29)17(18)20(28)26-12-13-7-8-14(22)11-16(13)23/h5-8,10-11,24,30H,2-4,9,12H2,1H3,(H,26,28)
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n/an/a 24n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020282
PNG
(CHEMBL3288831)
Show SMILES COC(=O)[C@@H](C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O5/c1-10(20(29)31-2)25-16-13-4-3-7-23-17(13)26(30)19(28)15(16)18(27)24-9-11-5-6-12(21)8-14(11)22/h3-8,10,25,30H,9H2,1-2H3,(H,24,27)/t10-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020279
PNG
(CHEMBL3288828)
Show SMILES CC(=O)OCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C20H18F2N4O5/c1-11(27)31-8-7-23-17-14-3-2-6-24-18(14)26(30)20(29)16(17)19(28)25-10-12-4-5-13(21)9-15(12)22/h2-6,9,23,30H,7-8,10H2,1H3,(H,25,28)
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n/an/a 27n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020260
PNG
(CHEMBL3288818)
Show SMILES CNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C17H14F2N4O3/c1-20-14-11-3-2-6-21-15(11)23(26)17(25)13(14)16(24)22-8-9-4-5-10(18)7-12(9)19/h2-7,20,26H,8H2,1H3,(H,22,24)
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n/an/a 27n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020277
PNG
(CHEMBL3288826)
Show SMILES NCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C18H17F2N5O3/c19-11-4-3-10(13(20)8-11)9-24-17(26)14-15(22-7-5-21)12-2-1-6-23-16(12)25(28)18(14)27/h1-4,6,8,22,28H,5,7,9,21H2,(H,24,26)
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n/an/a 39n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020265
PNG
(CHEMBL3288822)
Show SMILES On1c2ncccc2c(NCCc2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C24H20F2N4O3/c25-17-9-8-16(19(26)13-17)14-29-23(31)20-21(27-12-10-15-5-2-1-3-6-15)18-7-4-11-28-22(18)30(33)24(20)32/h1-9,11,13,27,33H,10,12,14H2,(H,29,31)
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n/an/a 50n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020263
PNG
(CHEMBL3288820)
Show SMILES On1c2ncccc2c(N2CCOCC2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C20H18F2N4O4/c21-13-4-3-12(15(22)10-13)11-24-19(27)16-17(25-6-8-30-9-7-25)14-2-1-5-23-18(14)26(29)20(16)28/h1-5,10,29H,6-9,11H2,(H,24,27)
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n/an/a 79n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50130699
PNG
(1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methy...)
Show SMILES Cc1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C=C2)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C10H15N2O13P3/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17/h2-4,7-8H,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/p-4/t7-,8+/m0/s1
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n/an/a 80n/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Reverse transcriptase (RT)

J Med Chem 46: 3292-9 (2003)


Article DOI: 10.1021/jm030116g
BindingDB Entry DOI: 10.7270/Q2PR7WRP
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020262
PNG
(CHEMBL3288819)
Show SMILES CN(C)c1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C18H16F2N4O3/c1-23(2)15-12-4-3-7-21-16(12)24(27)18(26)14(15)17(25)22-9-10-5-6-11(19)8-13(10)20/h3-8,27H,9H2,1-2H3,(H,22,25)
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n/an/a 87n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50481090
PNG
(CHEMBL567882)
Show SMILES Cc1cccc2COP(=O)(OC[C@H]3C[C@H](C[C@@H]3O)n3cc(C)c(=O)[nH]c3=O)Oc12 |r|
Show InChI InChI=1S/C19H23N2O7P/c1-11-4-3-5-13-9-26-29(25,28-17(11)13)27-10-14-6-15(7-16(14)22)21-8-12(2)18(23)20-19(21)24/h3-5,8,14-16,22H,6-7,9-10H2,1-2H3,(H,20,23,24)/t14-,15-,16+,29?/m1/s1
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n/an/a 120n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as lu...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020257
PNG
(CHEMBL3288816)
Show SMILES Nc1ccc(cc1)-c1ccc(Nc2c(C(=O)NCc3ccc(F)cc3F)c(=O)n(O)c3ncccc23)cc1
Show InChI InChI=1S/C28H21F2N5O3/c29-19-8-3-18(23(30)14-19)15-33-27(36)24-25(22-2-1-13-32-26(22)35(38)28(24)37)34-21-11-6-17(7-12-21)16-4-9-20(31)10-5-16/h1-14,34,38H,15,31H2,(H,33,36)
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n/an/a 130n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020256
PNG
(CHEMBL3288815)
Show SMILES On1c2ncccc2c(Nc2ccc(cc2)-c2ccc(cc2)C#N)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C29H19F2N5O3/c30-21-10-7-20(24(31)14-21)16-34-28(37)25-26(23-2-1-13-33-27(23)36(39)29(25)38)35-22-11-8-19(9-12-22)18-5-3-17(15-32)4-6-18/h1-14,35,39H,16H2,(H,34,37)
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n/an/a 130n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase protein


(Human immunodeficiency virus 1)		BDBM50481091
PNG
(CHEMBL27473)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CO)C2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C11H16N2O4/c1-6-4-13(11(17)12-10(6)16)8-2-7(5-14)9(15)3-8/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8-,9+/m1/s1
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n/an/a 190n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020266
PNG
(CHEMBL3288823)
Show SMILES On1c2ncccc2c(NCCCCc2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C26H24F2N4O3/c27-19-12-11-18(21(28)15-19)16-31-25(33)22-23(20-10-6-14-30-24(20)32(35)26(22)34)29-13-5-4-9-17-7-2-1-3-8-17/h1-3,6-8,10-12,14-15,29,35H,4-5,9,13,16H2,(H,31,33)
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n/an/a 280n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020308
PNG
(CHEMBL3288836)
Show SMILES CCOC(=O)[C@@H]1CCCN1c1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C23H22F2N4O5/c1-2-34-23(32)17-6-4-10-28(17)19-15-5-3-9-26-20(15)29(33)22(31)18(19)21(30)27-12-13-7-8-14(24)11-16(13)25/h3,5,7-9,11,17,33H,2,4,6,10,12H2,1H3,(H,27,30)/t17-/m0/s1
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n/an/a 310n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020252
PNG
(CHEMBL3288813)
Show SMILES On1c2ncccc2c(Nc2ccc(cc2)-c2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C28H20F2N4O3/c29-20-11-8-19(23(30)15-20)16-32-27(35)24-25(22-7-4-14-31-26(22)34(37)28(24)36)33-21-12-9-18(10-13-21)17-5-2-1-3-6-17/h1-15,33,37H,16H2,(H,32,35)
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n/an/a 340n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50481090
PNG
(CHEMBL567882)
Show SMILES Cc1cccc2COP(=O)(OC[C@H]3C[C@H](C[C@@H]3O)n3cc(C)c(=O)[nH]c3=O)Oc12 |r|
Show InChI InChI=1S/C19H23N2O7P/c1-11-4-3-5-13-9-26-29(25,28-17(11)13)27-10-14-6-15(7-16(14)22)21-8-12(2)18(23)20-19(21)24/h3-5,8,14-16,22H,6-7,9-10H2,1-2H3,(H,20,23,24)/t14-,15-,16+,29?/m1/s1
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n/an/a 380n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020264
PNG
(CHEMBL3288821)
Show SMILES On1c2ncccc2c(NC2CCCCCC2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C23H24F2N4O3/c24-15-10-9-14(18(25)12-15)13-27-22(30)19-20(28-16-6-3-1-2-4-7-16)17-8-5-11-26-21(17)29(32)23(19)31/h5,8-12,16,28,32H,1-4,6-7,13H2,(H,27,30)
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n/an/a 460n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM10245
PNG
(3-(2,6-difluorophenyl)-4-thia-2,7-diazatricyclo[6....)
Show SMILES Fc1cccc(F)c1C1SCc2nc3ccccc3n12
Show InChI InChI=1S/C15H10F2N2S/c16-9-4-3-5-10(17)14(9)15-19-12-7-2-1-6-11(12)18-13(19)8-20-15/h1-7,15H,8H2
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n/an/a 500n/an/an/an/an/an/a



National Cancer Institute-Frederick Cancer Research and Development Center

Curated by ChEMBL


Assay Description
The quantity of compound required to reduce WT Reverse transcriptase activity by 50%

J Med Chem 40: 4199-207 (1998)


Article DOI: 10.1021/jm970096g
BindingDB Entry DOI: 10.7270/Q25B01KN
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020278
PNG
(CHEMBL3288827)
Show SMILES OCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C18H16F2N4O4/c19-11-4-3-10(13(20)8-11)9-23-17(26)14-15(21-6-7-25)12-2-1-5-22-16(12)24(28)18(14)27/h1-5,8,21,25,28H,6-7,9H2,(H,23,26)
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n/an/a 550n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50130700
PNG
(1-(5-Hydroxymethyl-bicyclo[3.1.0]hex-3-en-2-yl)-5-...)
Show SMILES Cc1cn(C2C=C[C@]3(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C[C@H]23)c(=O)[nH]c1=O |c:5|
Show InChI InChI=1S/C12H17N2O12P3/c1-7-5-14(11(16)13-10(7)15)9-2-3-12(4-8(9)12)6-24-28(20,21)26-29(22,23)25-27(17,18)19/h2-3,5,8-9H,4,6H2,1H3,(H,20,21)(H,22,23)(H,13,15,16)(H2,17,18,19)/p-4/t8-,9?,12-/m1/s1
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n/an/a 650n/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Reverse transcriptase (RT)

J Med Chem 46: 3292-9 (2003)


Article DOI: 10.1021/jm030116g
BindingDB Entry DOI: 10.7270/Q2PR7WRP
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020280
PNG
(CHEMBL3288829)
Show SMILES COC(=O)CNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C19H16F2N4O5/c1-30-14(26)9-23-16-12-3-2-6-22-17(12)25(29)19(28)15(16)18(27)24-8-10-4-5-11(20)7-13(10)21/h2-7,23,29H,8-9H2,1H3,(H,24,27)
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n/an/a 710n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50481091
PNG
(CHEMBL27473)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CO)C2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C11H16N2O4/c1-6-4-13(11(17)12-10(6)16)8-2-7(5-14)9(15)3-8/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8-,9+/m1/s1
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n/an/a 830n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as lu...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020253
PNG
(CHEMBL3288814)
Show SMILES On1c2ncccc2c(Nc2ccc-3c(Cc4ccccc-34)c2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C29H20F2N4O3/c30-19-8-7-17(24(31)14-19)15-33-28(36)25-26(23-6-3-11-32-27(23)35(38)29(25)37)34-20-9-10-22-18(13-20)12-16-4-1-2-5-21(16)22/h1-11,13-14,34,38H,12,15H2,(H,33,36)
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n/an/a 840n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Reverse transcriptase/RNaseH


(Human immunodeficiency virus 1)		BDBM50061574
PNG
(1-Benzyl-2-(2,6-difluoro-phenyl)-4-methyl-1H-benzo...)
Show SMILES Cc1cccc2n(Cc3ccccc3)c(nc12)-c1c(F)cccc1F |(7.92,-7.8,;7.93,-9.34,;6.6,-10.13,;6.6,-11.67,;7.93,-12.44,;9.27,-11.65,;10.74,-12.12,;11.23,-13.59,;10.2,-14.73,;8.7,-14.42,;7.68,-15.57,;8.17,-17.03,;9.68,-17.34,;10.69,-16.19,;11.65,-10.87,;10.73,-9.62,;9.27,-10.11,;13.18,-10.86,;13.96,-12.19,;13.19,-13.53,;15.5,-12.19,;16.26,-10.85,;15.48,-9.5,;13.94,-9.53,;13.16,-8.2,)|
Show InChI InChI=1S/C21H16F2N2/c1-14-7-5-12-18-20(14)24-21(19-16(22)10-6-11-17(19)23)25(18)13-15-8-3-2-4-9-15/h2-12H,13H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



National Cancer Institute-Frederick Cancer Research and Development Center

Curated by ChEMBL


Assay Description
The quantity of compound required to reduce WT Reverse transcriptase activity by 50%

J Med Chem 40: 4199-207 (1998)


Article DOI: 10.1021/jm970096g
BindingDB Entry DOI: 10.7270/Q25B01KN
More data for this
Ligand-Target Pair
Reverse transcriptase protein


(Human immunodeficiency virus 1)		BDBM50481091
PNG
(CHEMBL27473)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CO)C2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C11H16N2O4/c1-6-4-13(11(17)12-10(6)16)8-2-7(5-14)9(15)3-8/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8-,9+/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs b...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020276
PNG
(CHEMBL3288825)
Show SMILES CC(C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C19H18F2N4O3/c1-10(2)24-16-13-4-3-7-22-17(13)25(28)19(27)15(16)18(26)23-9-11-5-6-12(20)8-14(11)21/h3-8,10,24,28H,9H2,1-2H3,(H,23,26)
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020309
PNG
(CHEMBL3288837)
Show SMILES Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C16H12F2N4O3/c17-9-4-3-8(11(18)6-9)7-21-15(23)12-13(19)10-2-1-5-20-14(10)22(25)16(12)24/h1-6,25H,7,19H2,(H,21,23)
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n/an/a 2.50E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50481091
PNG
(CHEMBL27473)
Show SMILES Cc1cn([C@H]2C[C@H](O)[C@@H](CO)C2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C11H16N2O4/c1-6-4-13(11(17)12-10(6)16)8-2-7(5-14)9(15)3-8/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8-,9+/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Reverse transcriptase protein


(Human immunodeficiency virus 1)		BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



NCI-Frederick

Curated by ChEMBL


Assay Description
Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs b...

J Med Chem 52: 5356-64 (2009)


Article DOI: 10.1021/jm801176e
BindingDB Entry DOI: 10.7270/Q29026MQ
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020260
PNG
(CHEMBL3288818)
Show SMILES CNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C17H14F2N4O3/c1-20-14-11-3-2-6-21-15(11)23(26)17(25)13(14)16(24)22-8-9-4-5-10(18)7-12(9)19/h2-7,20,26H,8H2,1H3,(H,22,24)
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n/an/a 3.70E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020307
PNG
(CHEMBL3288835)
Show SMILES COC(=O)[C@@H](CO)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O6/c1-32-20(30)14(9-27)25-16-12-3-2-6-23-17(12)26(31)19(29)15(16)18(28)24-8-10-4-5-11(21)7-13(10)22/h2-7,14,25,27,31H,8-9H2,1H3,(H,24,28)/t14-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020277
PNG
(CHEMBL3288826)
Show SMILES NCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C18H17F2N5O3/c19-11-4-3-10(13(20)8-11)9-24-17(26)14-15(22-7-5-21)12-2-1-6-23-16(12)25(28)18(14)27/h1-4,6,8,22,28H,5,7,9,21H2,(H,24,26)
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n/an/a 4.50E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020279
PNG
(CHEMBL3288828)
Show SMILES CC(=O)OCCNc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12
Show InChI InChI=1S/C20H18F2N4O5/c1-11(27)31-8-7-23-17-14-3-2-6-24-18(14)26(30)20(29)16(17)19(28)25-10-12-4-5-13(21)9-15(12)22/h2-6,9,23,30H,7-8,10H2,1H3,(H,25,28)
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n/an/a 5.30E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020294
PNG
(CHEMBL3288834)
Show SMILES COC(=O)[C@H](CO)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O6/c1-32-20(30)14(9-27)25-16-12-3-2-6-23-17(12)26(31)19(29)15(16)18(28)24-8-10-4-5-11(21)7-13(10)22/h2-7,14,25,27,31H,8-9H2,1H3,(H,24,28)/t14-/m0/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020282
PNG
(CHEMBL3288831)
Show SMILES COC(=O)[C@@H](C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O5/c1-10(20(29)31-2)25-16-13-4-3-7-23-17(13)26(30)19(28)15(16)18(27)24-9-11-5-6-12(21)8-14(11)22/h3-8,10,25,30H,9H2,1-2H3,(H,24,27)/t10-/m1/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020259
PNG
(CHEMBL3288817)
Show SMILES On1c2ncccc2c(Nc2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C22H16F2N4O3/c23-14-9-8-13(17(24)11-14)12-26-21(29)18-19(27-15-5-2-1-3-6-15)16-7-4-10-25-20(16)28(31)22(18)30/h1-11,27,31H,12H2,(H,26,29)
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n/an/a 6.90E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020281
PNG
(CHEMBL3288830)
Show SMILES COC(=O)[C@H](C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r|
Show InChI InChI=1S/C20H18F2N4O5/c1-10(20(29)31-2)25-16-13-4-3-7-23-17(13)26(30)19(28)15(16)18(27)24-9-11-5-6-12(21)8-14(11)22/h3-8,10,25,30H,9H2,1-2H3,(H,24,27)/t10-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50020265
PNG
(CHEMBL3288822)
Show SMILES On1c2ncccc2c(NCCc2ccccc2)c(C(=O)NCc2ccc(F)cc2F)c1=O
Show InChI InChI=1S/C24H20F2N4O3/c25-17-9-8-16(19(26)13-17)14-29-23(31)20-21(27-12-10-15-5-2-1-3-6-15)18-7-4-11-28-22(18)30(33)24(20)32/h1-9,11,13,27,33H,10,12,14H2,(H,29,31)
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n/an/a 8.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of 3'-processing activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrate

J Med Chem 57: 5190-202 (2014)


Article DOI: 10.1021/jm5001908
BindingDB Entry DOI: 10.7270/Q2JS9S0F
More data for this
Ligand-Target Pair
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