| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50020282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364988 (CHEMBL3295658) |
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| IC50 | 5800±n/a nM |
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| Citation |  Zhao, XZ; Smith, SJ; Métifiot, M; Marchand, C; Boyer, PL; Pommier, Y; Hughes, SH; Burke, TR 4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1. J Med Chem57:5190-202 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50020282 |
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| n/a |
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| Name | BDBM50020282 |
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| Synonyms: | CHEMBL3288831 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F2N4O5 |
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| Mol. Mass. | 432.3775 |
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| SMILES | COC(=O)[C@@H](C)Nc1c(C(=O)NCc2ccc(F)cc2F)c(=O)n(O)c2ncccc12 |r| |
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| Structure | 
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