| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50130713 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144608 (CHEMBL751027) |
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| IC50 | 200000±n/a nM |
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| Citation |  Filimonov, DA; Gomazkov, OA; Lagunin, AA; Gureeva, TA; Dilakyan, EA; Kugaevskaya, EV; Elisseeva, YE; Solovyeva, NI; Poroikov, VV Computer-aided selection of potential antihypertensive compounds with dual mechanism of action. J Med Chem46:3326-32 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
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| Type: | Protein |
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| Mol. Mass.: | 85789.59 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07861 |
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| Residue: | 750 |
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| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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| BDBM50130713 |
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| n/a |
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| Name | BDBM50130713 |
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| Synonyms: | CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoyl-propyl) ester |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17NO2S |
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| Mol. Mass. | 251.345 |
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| SMILES | CC(CSC(C)=O)C(=O)NCc1ccccc1 |
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| Structure | 
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