| Reaction Details |
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 | Report a problem with these data |
| Target | NH(3)-dependent NAD(+) synthetase |
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| Ligand | BDBM18069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_141613 (CHEMBL747929) |
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| IC50 | >1000±n/a nM |
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| Citation |  Velu, SE; Cristofoli, WA; Garcia, GJ; Brouillette, CG; Pierson, MC; Luan, CH; DeLucas, LJ; Brouillette, WJ Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem46:3371-81 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NH(3)-dependent NAD(+) synthetase |
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| Name: | NH(3)-dependent NAD(+) synthetase |
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| Synonyms: | GSP38 | General stress protein 38 | NADE_BACSU | Spore outgrowth factor B | Sporulation protein outB | nadE | outB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30386.77 |
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| Organism: | Bacillus subtilis |
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| Description: | ChEMBL_141613 |
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| Residue: | 272 |
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| Sequence: | MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQ
LAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQ
QETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLL
PLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKE
VSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
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| BDBM18069 |
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| n/a |
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| Name | BDBM18069 |
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| Synonyms: | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | CHEMBL22 | TMP | Trimethoprim | Trimethoprim (TMP) | US10870625, Compound TMP |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18N4O3 |
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| Mol. Mass. | 290.3177 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
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| Structure | 
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