| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
|---|
| Ligand | BDBM50131934 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_58521 (CHEMBL672016) |
|---|
| Ki | 1350±n/a nM |
|---|
| Citation |  Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. J Med Chem46:3822-39 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(1A) dopamine receptor |
|---|
| Name: | D(1A) dopamine receptor |
|---|
| Synonyms: | DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49429.75 |
|---|
| Organism: | RAT |
|---|
| Description: | P18901 |
|---|
| Residue: | 446 |
|---|
| Sequence: | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNF
FVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDR
YWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLED
TEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKN
CQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGS
EETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPVTHSGQHST
|
|
|
|---|
| BDBM50131934 |
|---|
| n/a |
|---|
| Name | BDBM50131934 |
|---|
| Synonyms: | CHEMBL126439 | CHEMBL127317 | Quinoline-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H30N4O2 |
|---|
| Mol. Mass. | 418.5313 |
|---|
| SMILES | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
