Reaction Details |
| Report a problem with these data |
Target | Equilibrative nucleoside transporter 1 |
---|
Ligand | BDBM50370291 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_144063 (CHEMBL752093) |
---|
Ki | 0.45±n/a nM |
---|
Citation | Zhu, Z; Furr, J; Buolamwini, JK Synthesis and flow cytometric evaluation of novel 1,2,3,4-tetrahydroisoquinoline conformationally constrained analogues of nitrobenzylmercaptopurine riboside (NBMPR) designed for probing its conformation when bound to the es nucleoside transporter. J Med Chem46:831-7 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Equilibrative nucleoside transporter 1 |
---|
Name: | Equilibrative nucleoside transporter 1 |
Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 50225.92 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 456 |
Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
|
|
|
BDBM50370291 |
---|
n/a |
---|
Name | BDBM50370291 |
Synonyms: | CHEMBL608208 |
Type | Small organic molecule |
Emp. Form. | C19H20N6O6 |
Mol. Mass. | 428.3987 |
SMILES | OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(ncnc12)N1CCc2ccc(cc2C1)[N+]([O-])=O |r| |
Structure |
|