| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Ligand | BDBM50125935 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144957 (CHEMBL755075) |
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| IC50 | 50000±n/a nM |
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| Citation |  Husain, SS; Ziebell, MR; Ruesch, D; Hong, F; Arevalo, E; Kosterlitz, JA; Olsen, RW; Forman, SA; Cohen, JB; Miller, KW 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem46:1257-65 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Name: | Acetylcholine receptor subunit alpha/beta/delta/gamma |
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| Synonyms: | Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 144957 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | Acetylcholine receptor subunit alpha |
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| Synonyms: | ACHA_MOUSE | Acetylcholine receptor subunit alpha | Acra | Chrna1 | n-AChR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51932.98 |
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| Organism: | MOUSE |
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| Description: | n-AChR 0 MOUSE::P04756 |
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| Residue: | 457 |
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| Sequence: | MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQL
INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDF
AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
ESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVII
PCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKR
IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWK
YVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG
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| Component 2 |
| Name: | Acetylcholine receptor subunit beta |
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| Synonyms: | ACHB_MOUSE | Acetylcholine receptor protein beta chain | Acrb | Chrnb1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56919.84 |
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| Organism: | Mus musculus |
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| Description: | EBI_11803 |
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| Residue: | 501 |
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| Sequence: | MALGALLLLLGVLGTPLAPGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTL
AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND
GNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS
LKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLIQLPGDQRGGKEGHHEEVIFYLI
IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE
TSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGL
KRPKPERDQLPEPHHSLSPRSGWGRGTDEYFIRKPPSDFLFPKLNRFQPESSAPDLRRFI
DGPTRAVGLPQELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTS
VGTLVIFLDATYHLPPPEPFP
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| Component 3 |
| Name: | Acetylcholine receptor subunit gamma |
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| Synonyms: | ACHG_MOUSE | Acetylcholine receptor subunit gamma | Acrg | Chrng |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58747.23 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_107886 |
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| Residue: | 519 |
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| Sequence: | MQGGQRPHLLLLLLAVCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLT
NLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWRPDIVLENNVDG
VFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLIFQSQTYSTSEINL
QLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLDSVAPAEEAGHQKVVFYLLIQRK
PLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQ
AVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKLFLRLLPQLLRMHVR
PLAPAAVQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENG
PEVRQSQEFCGSLKQASPAIQACVDACNLMARARRQQSHFDSGNEEWLLVGRVLDRVCFL
AMLSLFICGTAGIFLMAHYNQVPDLPFPGDPRPYLPLPD
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| Component 4 |
| Name: | Acetylcholine receptor subunit delta |
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| Synonyms: | ACHD_MOUSE | Acetylcholine receptor protein delta chain | Acrd | Chrnd |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59138.17 |
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| Organism: | Mus musculus |
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| Description: | EBI_100149 |
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| Residue: | 520 |
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| Sequence: | MAGPVLTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALS
LTLSNLISLKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLEN
NNDGSFQISYACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAK
EITLSLKQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVT
FYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISK
RLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPK
LLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFSLKSRSDLMFEKQSERHGLARRLTTA
RRPPASSEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVV
TPVMVVGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI
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| BDBM50125935 |
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| n/a |
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| Name | BDBM50125935 |
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| Synonyms: | (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester | (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylicacid ethyl ester | 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester | Amidate | CHEMBL681 | Etomidate | R(+)-etomidate | R-ETOMIDATE |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O2 |
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| Mol. Mass. | 244.289 |
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| SMILES | CCOC(=O)c1cncn1[C@H](C)c1ccccc1 |r| |
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| Structure | 
|
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