BindingDB PrimarySearch

Found 53 hits with Last Name = 'forman' and Initial = 'sa'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551943 (CHEMBL2163550) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]pTFD-di-iPr-BnOH labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction i...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50395121 (CHEMBL2163548) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged alpha1 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit beta-3 (Homo sapiens (Human))	BDBM50395121 (CHEMBL2163548) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in ph...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]pTFD-di-iPr-BnOH labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction i...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (Torpedo californica)	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (MOUSE-Mus musculus)	BDBM50125934 (3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]R-mTFD-MPAB labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in pho...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]pTFD-di-iPr-BnOH labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction i...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-9 (RAT)	BDBM50079884 (2-(3-Pentyl-3H-diazirin-3-yl)-ethanol \| CHEMBL1118...) Show SMILES CCCCCC1(CCO)N=N1 \|c:9\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description The compound was tested for inhibitory potency against Nicotinic acetylcholine receptor in Rat muscle.				J Med Chem 42: 3300-7 (1999) Article DOI: 10.1021/jm9806300 BindingDB Entry DOI: 10.7270/Q28P5ZPF
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (Torpedo californica)	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-[125I]-A-85,380 binding to alpha2 beta4 nicotinic acetylcholine receptor (nAChR) in rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]R-mTFD-MPAB labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in pho...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (MOUSE-Mus musculus)	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125939 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit beta-3 (Homo sapiens (Human))	BDBM50055935 (5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...) Show SMILES CCCC(C)C1(CC)C(=O)NC(=O)NC1=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551941 (CHEMBL4748056) Show SMILES CC(C)c1cccc(C(C)C)c1CO Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in ph...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50395120 (CHEMBL2163549) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged alpha1 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit beta-3 (Homo sapiens (Human))	BDBM50395120 (CHEMBL2163549) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551941 (CHEMBL4748056) Show SMILES CC(C)c1cccc(C(C)C)c1CO Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.43E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]R-mTFD-MPAB labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in pho...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125937 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES CCOC(=O)c1cncn1[C@@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551940 (CHEMBL4741515) Show SMILES OCc1ccc(cc1)C1(N=N1)C(F)(F)F \|c:10\| Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.05E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in ph...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in ph...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551940 (CHEMBL4741515) Show SMILES OCc1ccc(cc1)C1(N=N1)C(F)(F)F \|c:10\| Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.65E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of [3H]R-mTFD-MPAB labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in pho...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.77E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM50055935 (5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...) Show SMILES CCCC(C)C1(CC)C(=O)NC(=O)NC1=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]R-(-)-14 from human FLAG-tagged alpha1 GABA A receptor expressed in HEK293S cells				J Med Chem 55: 6554-65 (2012) Article DOI: 10.1021/jm300631e BindingDB Entry DOI: 10.7270/Q25B03MX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GABA-induced ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]flunitrazepam binding measured aft...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3 in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10 mins b...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551942 (CHEMBL4748423) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551941 (CHEMBL4748056) Show SMILES CC(C)c1cccc(C(C)C)c1CO Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50551940 (CHEMBL4741515) Show SMILES OCc1ccc(cc1)C1(N=N1)C(F)(F)F \|c:10\| Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM16418 (benzyl alcohol \| phenylmethanol) Show SMILES OCc1ccccc1 Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+7	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112261 BindingDB Entry DOI: 10.7270/Q2R78JT8
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50482885 (CHEMBL1270457) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Agonist activity at human GABA-A alpha-1-beta-2-gamma-2 receptor expressed in Xenopus laevis				J Med Chem 53: 6432-44 (2010) Article DOI: 10.1021/jm100498u BindingDB Entry DOI: 10.7270/Q2959MCX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50482884 (CHEMBL1270361) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Agonist activity at human GABA-A alpha-1-beta-2-gamma-2 receptor expressed in Xenopus laevis				J Med Chem 53: 6432-44 (2010) Article DOI: 10.1021/jm100498u BindingDB Entry DOI: 10.7270/Q2959MCX
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50282234 (CHEMBL4163464) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50282235 (CHEMBL4174166) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	770	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50282235 (CHEMBL4174166) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164570 ((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50164570 ((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Compound was evaluated for OT receptor affinity by displacement of [3H]OT from binding sites in uterine tissue taken from pregnant rats				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50282234 (CHEMBL4163464) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50282235 (CHEMBL4174166) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50164570 ((3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Displacement of [3H]muscimol from human GABAA receptor alpha1beta3gamma2 expressed in HEK293 TetR cell membranes after 1 hr by liquid scintillation c...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50282234 (CHEMBL4163464) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...				Eur J Med Chem 136: 334-347 (2017) Article DOI: 10.1016/j.ejmech.2017.04.043 BindingDB Entry DOI: 10.7270/Q2K076TS
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125937 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES CCOC(=O)c1cncn1[C@@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABA				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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