Reaction Details |
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Target | Acetylcholine receptor subunit alpha/beta/delta/gamma |
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Ligand | BDBM50125935 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144959 (CHEMBL755077) |
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IC50 | 41000±n/a nM |
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Citation | Husain, SS; Ziebell, MR; Ruesch, D; Hong, F; Arevalo, E; Kosterlitz, JA; Olsen, RW; Forman, SA; Cohen, JB; Miller, KW 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem46:1257-65 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholine receptor subunit alpha/beta/delta/gamma |
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Name: | Acetylcholine receptor subunit alpha/beta/delta/gamma |
Synonyms: | Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 143080 |
Components: | This complex has 4 components. |
Component 1 |
Name: | Acetylcholine receptor subunit beta |
Synonyms: | ACHB_TETCF | Acetylcholine receptor | CHRNB1 |
Type: | PROTEIN |
Mol. Mass.: | 56146.98 |
Organism: | Torpedo californica |
Description: | EBI_19626 |
Residue: | 493 |
Sequence: | MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
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Component 2 |
Name: | Acetylcholine receptor subunit gamma |
Synonyms: | ACHG_TETCF | Acetylcholine receptor | CHRNG |
Type: | PROTEIN |
Mol. Mass.: | 58151.68 |
Organism: | Torpedo californica |
Description: | EBI_19662 |
Residue: | 506 |
Sequence: | MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
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Component 3 |
Name: | Acetylcholine receptor subunit alpha |
Synonyms: | ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1 |
Type: | PROTEIN |
Mol. Mass.: | 52735.09 |
Organism: | Torpedo californica |
Description: | ChEMBL_216981 |
Residue: | 461 |
Sequence: | MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
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Component 4 |
Name: | Acetylcholine receptor subunit delta |
Synonyms: | ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd |
Type: | PROTEIN |
Mol. Mass.: | 59885.01 |
Organism: | Torpedo californica |
Description: | ChEMBL_142744 |
Residue: | 522 |
Sequence: | MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
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BDBM50125935 |
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n/a |
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Name | BDBM50125935 |
Synonyms: | (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester | (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylicacid ethyl ester | 3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester | Amidate | CHEMBL681 | Etomidate | R(+)-etomidate | R-ETOMIDATE |
Type | Small organic molecule |
Emp. Form. | C14H16N2O2 |
Mol. Mass. | 244.289 |
SMILES | CCOC(=O)c1cncn1[C@H](C)c1ccccc1 |r| |
Structure |
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