| Reaction Details |
|---|
 | Report a problem with these data |
| Target | B2 bradykinin receptor |
|---|
| Ligand | BDBM50146893 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_40267 (CHEMBL656503) |
|---|
| IC50 | 0.19±n/a nM |
|---|
| Citation |  Sawada, Y; Kayakiri, H; Abe, Y; Mizutani, T; Inamura, N; Asano, M; Hatori, C; Aramori, I; Oku, T; Tanaka, H Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks. J Med Chem47:2853-63 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| B2 bradykinin receptor |
|---|
| Name: | B2 bradykinin receptor |
|---|
| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 44467.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
|---|
| Residue: | 391 |
|---|
| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
|
|
|
|---|
| BDBM50146893 |
|---|
| n/a |
|---|
| Name | BDBM50146893 |
|---|
| Synonyms: | 4-{(E)-2-[({[2,4-Dichloro-3-(4-ethoxy-2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-vinyl}-N-methyl-benzamide; hydrochloride | CHEMBL555403 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H32Cl2N4O5 |
|---|
| Mol. Mass. | 635.537 |
|---|
| SMILES | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)\C=C\c4ccc(cc4)C(=O)NC)c3Cl)cccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
