| Reaction Details |
|---|
 | Report a problem with these data |
| Target | B2 bradykinin receptor |
|---|
| Ligand | BDBM50142953 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_40292 (CHEMBL653424) |
|---|
| IC50 | 0.430±n/a nM |
|---|
| Citation |  Sawada, Y; Kayakiri, H; Abe, Y; Imai, K; Mizutani, T; Inamura, N; Asano, M; Aramori, I; Hatori, C; Katayama, A; Oku, T; Tanaka, H A new series of highly potent non-peptide bradykinin B2 receptor antagonists incorporating the 4-heteroarylquinoline framework. Improvement of aqueous solubility and new insights into species difference. J Med Chem47:1617-30 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| B2 bradykinin receptor |
|---|
| Name: | B2 bradykinin receptor |
|---|
| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 44467.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
|---|
| Residue: | 391 |
|---|
| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
|
|
|
|---|
| BDBM50142953 |
|---|
| n/a |
|---|
| Name | BDBM50142953 |
|---|
| Synonyms: | 4-[(E)-2-({1-[2,4-Dichloro-3-(4-imidazol-1-yl-2-methyl-quinolin-8-yloxymethyl)-phenyl]-1H-pyrrol-2-ylmethyl}-carbamoyl)-vinyl]-N-pyridin-2-ylmethyl-benzamide; trihydrochloride | CHEMBL543068 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C41H33Cl2N7O3 |
|---|
| Mol. Mass. | 742.652 |
|---|
| SMILES | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(c3Cl)-n3cccc3CNC(=O)\C=C\c3ccc(cc3)C(=O)NCc3ccccn3)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
