| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50142990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_79980 (CHEMBL690417) |
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| Ki | 0.4±n/a nM |
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| Citation |  Reid, RC; Pattenden, LK; Tyndall, JD; Martin, JL; Walsh, T; Fairlie, DP Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries. J Med Chem47:1641-51 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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| BDBM50142990 |
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| n/a |
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| Name | BDBM50142990 |
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| Synonyms: | CHEMBL288836 | N-[(R)-2-Hydroxy-2-((9S,12S)-9-isopropyl-7,10-dioxo-2-oxa-8,11-diaza-bicyclo[12.2.2]octadeca-1(17),14(18),15-trien-12-yl)-ethyl]-N-(3-methyl-butyl)-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H45N3O6S |
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| Mol. Mass. | 587.771 |
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| SMILES | CC(C)CCN(C[C@@H](O)[C@@H]1Cc2ccc(OCCCCC(=O)N[C@@H](C(C)C)C(=O)N1)cc2)S(=O)(=O)c1ccccc1 |
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| Structure | 
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