| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50098777 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63358 (CHEMBL679122) |
|---|
| IC50 | 0.04±n/a nM |
|---|
| Citation |  Wu, C; Decker, ER; Blok, N; Bui, H; You, TJ; Wang, J; Bourgoyne, AR; Knowles, V; Berens, KL; Holland, GW; Brock, TA; Dixon, RA Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. J Med Chem47:1969-86 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48256.91 |
|---|
| Organism: | RAT |
|---|
| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
|
|
|
|---|
| BDBM50098777 |
|---|
| n/a |
|---|
| Name | BDBM50098777 |
|---|
| Synonyms: | 3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (2-acetyl-4,6-dimethyl-phenyl)-amide | CHEMBL19950 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18ClN3O5S2 |
|---|
| Mol. Mass. | 467.946 |
|---|
| SMILES | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
