Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50144883

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_106506 (CHEMBL715500)

158.49±n/a nM

Citation

Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands. J Med Chem47:2194-207 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

MC4-R | MC4R_MOUSE | Mc4r

Type:

PROTEIN

Mol. Mass.:

36964.43

Organism:

Mus musculus

Description:

ChEMBL_1498850

Residue:

332

Sequence:

MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY

BDBM50144883

n/a

Name

BDBM50144883

Synonyms:

(3S)-4-(4-hydroxyphenyl)-2-oxo-3-{[(6S,9R,12S,15S,18R,21S,24R,27S)-9,18,21-tribenzyl-15-(carbamoylmethyl)-24-{3-[(diaminomethylidene)amino]propyl}-27-[(2S)-2-hydrazinyl-3-(4-hydroxyphenyl)propanamido]-12-methyl-8,11,14,17,20,23,26-heptaoxo-1,2,3,4-tetrathia-7,10,13,16,19,22,25-heptaazacyclooctacosan-6-yl]formamido}butanamide | CHEMBL409190

Type

Small organic molecule

Emp. Form.

C65H80N16O14S4

Mol. Mass.

1437.69

SMILES

C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CSSSSC[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN

Structure