| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50150499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305554 (CHEMBL828573) |
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| IC50 | 10±n/a nM |
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| Citation |  Ueno, H; Katoh, S; Yokota, K; Hoshi, J; Hayashi, M; Uchida, I; Aisaka, K; Hase, Y; Cho, H Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa. Bioorg Med Chem Lett14:4281-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50150499 |
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| n/a |
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| Name | BDBM50150499 |
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| Synonyms: | CHEMBL536722 | N-(5-Carbamimidoyl-1-cyclohexylcarbamoylmethyl-1H-benzoimidazol-2-ylmethyl)-N-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-terephthalamic acid; dihydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C38H44N8O5 |
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| Mol. Mass. | 692.8066 |
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| SMILES | CC(=N)N1CCC(CC1)Oc1ccc(cc1)N(Cc1nc2cc(ccc2n1CC(=O)NC1CCCCC1)C(N)=N)C(=O)c1ccc(cc1)C(O)=O |
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| Structure | 
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