| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
|---|
| Ligand | BDBM50155386 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304771 (CHEMBL828537) |
|---|
| Ki | 140±n/a nM |
|---|
| Citation |  Pontillo, J; Tran, JA; Fleck, BA; Marinkovic, D; Arellano, M; Tucci, FC; Lanier, M; Nelson, J; Parker, J; Saunders, J; Murphy, B; Foster, AC; Chen, C Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett14:5605-9 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 4 |
|---|
| Name: | Melanocortin receptor 4 |
|---|
| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36949.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P32245 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
|
|
|
|---|
| BDBM50155386 |
|---|
| n/a |
|---|
| Name | BDBM50155386 |
|---|
| Synonyms: | 3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(2-thiophen-2-yl-ethylamino)-propyl]-phenyl}-piperazin-1-yl)-ethyl]-propionamide | CHEMBL264983 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H40ClN5O2S |
|---|
| Mol. Mass. | 582.2 |
|---|
| SMILES | CCC(NCCc1cccs1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CCN |
|---|
| Structure | 
|
|---|
Search and Browse
