| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50155391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304771 (CHEMBL828537) |
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| Ki | 5400±n/a nM |
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| Citation |  Pontillo, J; Tran, JA; Fleck, BA; Marinkovic, D; Arellano, M; Tucci, FC; Lanier, M; Nelson, J; Parker, J; Saunders, J; Murphy, B; Foster, AC; Chen, C Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett14:5605-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50155391 |
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| n/a |
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| Name | BDBM50155391 |
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| Synonyms: | 3-Amino-3-(4-chloro-phenyl)-1-(4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-propan-1-one | CHEMBL185852 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31ClN4OS |
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| Mol. Mass. | 483.069 |
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| SMILES | NC(CC(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1)c1ccc(Cl)cc1 |
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| Structure | 
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