| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
|---|
| Ligand | BDBM50145722 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304230 (CHEMBL829769) |
|---|
| EC50 | 1299±n/a nM |
|---|
| Citation |  Wang, M; Winneroski, LL; Ardecky, RJ; Babine, RE; Brooks, DA; Etgen, GJ; Hutchison, DR; Kauffman, RF; Kunkel, A; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, MK; Rito, CJ; Rungta, DK; Tripp, AE; Wilson, SB; Xu, Y; Zink, RW; McCarthy, JR Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis. Bioorg Med Chem Lett14:6113-6 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peroxisome proliferator-activated receptor alpha |
|---|
| Name: | Peroxisome proliferator-activated receptor alpha |
|---|
| Synonyms: | Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52343.28 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_572395 |
|---|
| Residue: | 468 |
|---|
| Sequence: | MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
|
|
|
|---|
| BDBM50145722 |
|---|
| n/a |
|---|
| Name | BDBM50145722 |
|---|
| Synonyms: | (S)-2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-phenoxy-propionic acid | CHEMBL81248 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27NO5 |
|---|
| Mol. Mass. | 457.5177 |
|---|
| SMILES | Cc1oc(nc1CCOc1ccc(C[C@](C)(Oc2ccccc2)C(O)=O)cc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
