Reaction Details |
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Target | Prostaglandin E2 receptor EP1 subtype |
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Ligand | BDBM50159758 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302794 (CHEMBL839478) |
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Ki | 13000±n/a nM |
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Citation | Belley, M; Gallant, M; Roy, B; Houde, K; Lachance, N; Labelle, M; Trimble, LA; Chauret, N; Li, C; Sawyer, N; Tremblay, N; Lamontagne, S; Carrière, MC; Denis, D; Greig, GM; Slipetz, D; Metters, KM; Gordon, R; Chan, CC; Zamboni, RJ Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists. Bioorg Med Chem Lett15:527-30 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E2 receptor EP1 subtype |
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Name: | Prostaglandin E2 receptor EP1 subtype |
Synonyms: | PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor |
Type: | Enzyme |
Mol. Mass.: | 41834.57 |
Organism: | Homo sapiens (Human) |
Description: | P34995 |
Residue: | 402 |
Sequence: | MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA
AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF
GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE
LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR
PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR
QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
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BDBM50159758 |
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n/a |
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Name | BDBM50159758 |
Synonyms: | 3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-methyl-phenyl]-3-hydroxy-propenyl}-phenyl)-acrylic acid | CHEMBL360290 |
Type | Small organic molecule |
Emp. Form. | C26H22Cl2O4 |
Mol. Mass. | 469.356 |
SMILES | Cc1cccc(C(O)\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl |
Structure |
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