| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50165118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305877 (CHEMBL831921) |
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| IC50 | >400000±n/a nM |
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| Citation |  Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg Med Chem Lett15:2177-80 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 25095.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06730 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50165118 |
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| n/a |
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| Name | BDBM50165118 |
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| Synonyms: | 2-Amino-7-benzyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium | CHEMBL382100 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32N5O5 |
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| Mol. Mass. | 458.5301 |
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| SMILES | CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc(N)[nH]c2=O |
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| Structure | 
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