Compile Data Set for Download or QSAR

Found 66 hits with Last Name = 'bitterman' and Initial = 'pb'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assa...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in human PBMC preincubated for 4 hrs assessed after 5 hrs of LPS challenge by one stage clotting ass...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19130 ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of IL-1-beta-induced tissue factor activity in human PBMC preincubated for 4 hrs assessed after 5 hrs of IL1-beta challenge by one stage c...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50238632 ((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O |r| Show InChI InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50238632 ((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]2CCCCN2C1=O |r| Show InChI InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410170 (CHEMBL2079703) Show SMILES C[n+]1cn([C@H]2C[C@@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O2)c2nc([NH-])[nH]c(=O)c12 Show InChI InChI=1S/C11H18N5O13P3/c1-15-4-16(9-8(15)10(18)14-11(12)13-9)7-2-5(17)6(27-7)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h4-7,17H,2-3H2,1H3,(H6-,12,13,14,18,19,20,21,22,23,24,25)/p-4/t5-,6-,7-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370488 (CHEMBL607618) Show SMILES C[n+]1cn(C2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r| Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-3/t4-,6-,7-,10?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19410 (CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...) Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1 Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM19410 (CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...) Show SMILES Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1 Show InChI InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410173 (CHEMBL2079719) Show SMILES CC[n+]1cn(C2OC(COP([O-])=O)C(OC(C)C)C2OC(C)C)c2nc(N)[n-]c(=O)c12 Show InChI InChI=1S/C18H30N5O7P/c1-6-22-8-23(15-12(22)16(24)21-18(19)20-15)17-14(29-10(4)5)13(28-9(2)3)11(30-17)7-27-31(25)26/h8-11,13-14,17,31H,6-7H2,1-5H3,(H3-,19,20,21,24,25,26)/p-1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370490 (CHEMBL610599) Show SMILES C[n+]1cn(C2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r| Show InChI InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/p-1/t4-,6-,7-,10?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410172 (CHEMBL2079724) Show SMILES CC(C)OC1C(COP([O-])=O)OC(C1OC(C)C)n1c[n+](C)c2c1nc(N)[n-]c2=O Show InChI InChI=1S/C17H28N5O7P/c1-8(2)27-12-10(6-26-30(24)25)29-16(13(12)28-9(3)4)22-7-21(5)11-14(22)19-17(18)20-15(11)23/h7-10,12-13,16,30H,6H2,1-5H3,(H3-,18,19,20,23,24,25)/p-1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410171 (CHEMBL2079700) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccccccc2)c2c1nc([NH-])[nH]c2=O Show InChI InChI=1S/C27H36N5O7P/c1-17(2)37-22-20(15-36-40(34)35)39-26(23(22)38-18(3)4)32-16-31(21-24(32)29-27(28)30-25(21)33)14-19-12-10-8-6-5-7-9-11-13-19/h5-13,16-18,20,22-23,26,40H,14-15H2,1-4H3,(H3-,28,29,30,33,34,35)/p-1/b6-5-,7-5-,8-6-,9-7-,10-8-,11-9-,12-10-,13-11-,19-12+,19-13+/t20-,22+,23?,26-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410174 (CHEMBL2079702) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc([NH-])[nH]c2=O Show InChI InChI=1S/C23H32N5O7P/c1-13(2)33-18-16(11-32-36(30)31)35-22(19(18)34-14(3)4)28-12-27(10-15-8-6-5-7-9-15)17-20(28)25-23(24)26-21(17)29/h5-9,12-14,16,18-19,22,36H,10-11H2,1-4H3,(H3-,24,25,26,29,30,31)/p-1/t16-,18+,19?,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370482 (CHEMBL610852) Show SMILES CC[n+]1cn(C2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r| Show InChI InChI=1S/C12H18N5O8P/c1-2-16-4-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(25-11)3-24-26(21,22)23/h4-5,7-8,11,18-19H,2-3H2,1H3,(H4-,13,14,15,20,21,22,23)/p-1/t5-,7-,8-,11?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370491 (CHEMBL611110) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](COP([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H14N5O7P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(22-9)1-21-23(19)20/h2-3,5-6,9,16-17,23H,1H2,(H,19,20)(H3,11,13,14,18)/p-1/t3-,5-,6-,9?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165117 (2-amino-6-hydroxy-9-[(2R,4S,5R)-5-[(phosphinatooxy...) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C16H26N5O7P/c1-7(2)26-11-9(5-25-29(23)24)28-15(12(11)27-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)22/h6-9,11-12,15,29H,5H2,1-4H3,(H,23,24)(H3,17,19,20,22)/t9-,11+,12?,15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370487 (CHEMBL609052) Show SMILES Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)C1O[C@H](COP([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H20N5O7P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(29-16)7-28-30(26)27/h1-5,8,10,12-13,16,23-24,30H,6-7H2,(H3-,18,19,20,25,26,27)/t10-,12-,13-,16?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370492 (CHEMBL607905) Show SMILES Nc1nc2n(c[n+](CC=C)c2c(=O)[nH]1)C1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H18N5O8P/c1-2-3-17-5-18(10-7(17)11(21)16-13(14)15-10)12-9(20)8(19)6(26-12)4-25-27(22,23)24/h2,5-6,8-9,12,19-20H,1,3-4H2,(H4-,14,15,16,21,22,23,24)/p-1/t6-,8-,9-,12?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370481 (CHEMBL611113) Show SMILES Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)C1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H20N5O8P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(30-16)7-29-31(26,27)28/h1-5,8,10,12-13,16,23-24H,6-7H2,(H4-,18,19,20,25,26,27,28)/p-1/t10-,12-,13-,16?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165116 (CHEMBL194007 | tetrasodium ({[(2R,3R,5R)-5-(2-amin...) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O1 Show InChI InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/p-4/t4-,5-,6-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165118 (2-Amino-7-benzyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4...) Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C23H31N5O5/c1-13(2)31-18-16(11-29)33-22(19(18)32-14(3)4)28-12-27(10-15-8-6-5-7-9-15)17-20(28)25-23(24)26-21(17)30/h5-9,12-14,16,18-19,22,29H,10-11H2,1-4H3,(H2-,24,25,26,30)/p+1/t16-,18+,19?,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165119 (2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopro...) Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](C)c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C17H27N5O5/c1-8(2)25-12-10(6-23)27-16(13(12)26-9(3)4)22-7-21(5)11-14(22)19-17(18)20-15(11)24/h7-10,12-13,16,23H,6H2,1-5H3,(H2-,18,19,20,24)/p+1/t10-,12+,13?,16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165122 (CHEMBL195283 | disodium 2-amino-9-[(2R,4S,5R)-5-[(...) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C19H31N6O9P/c1-9(2)32-14-11(7-31-35(29,30)22-6-5-12(26)27)34-18(15(14)33-10(3)4)25-8-21-13-16(25)23-19(20)24-17(13)28/h8-11,14-15,18H,5-7H2,1-4H3,(H,26,27)(H2,22,29,30)(H3,20,23,24,28)/p-1/t11-,14+,15?,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165127 (2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopro...) Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1cnc2c1nc(N)[nH]c2=O Show InChI InChI=1S/C16H25N5O5/c1-7(2)24-11-9(5-22)26-15(12(11)25-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)23/h6-9,11-12,15,22H,5H2,1-4H3,(H3,17,19,20,23)/t9-,11+,12?,15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370483 (CHEMBL607903) Show SMILES CN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)C2=NC=NC(O)C12 |r,c:16,t:14| Show InChI InChI=1S/C11H18N4O5/c1-14-4-15(9-6(14)10(19)13-3-12-9)11-8(18)7(17)5(2-16)20-11/h3,5-8,10-11,16-19H,2,4H2,1H3/t5-,6?,7-,8-,10?,11?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370484 (CHEMBL611105) Show SMILES C[n+]1cn(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r| Show InChI InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165134 (2-Amino-7-ethyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-...) Show SMILES CC[n+]1cn([C@@H]2O[C@H](CO)[C@H](OC(C)C)C2OC(C)C)c2nc(N)[nH]c(=O)c12 Show InChI InChI=1S/C18H29N5O5/c1-6-22-8-23(15-12(22)16(25)21-18(19)20-15)17-14(27-10(4)5)13(26-9(2)3)11(7-24)28-17/h8-11,13-14,17,24H,6-7H2,1-5H3,(H2-,19,20,21,25)/p+1/t11-,13+,14?,17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370485 (CHEMBL611114) Show SMILES Cc1ccc(SNc2nc3n(cnc3c(=O)[nH]2)C2O[C@H](CO)[C@@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C17H19N5O5S/c1-8-2-4-9(5-3-8)28-21-17-19-14-11(15(26)20-17)18-7-22(14)16-13(25)12(24)10(6-23)27-16/h2-5,7,10,12-13,16,23-25H,6H2,1H3,(H2,19,20,21,26)/t10-,12-,13-,16?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370486 (CHEMBL611097) Show SMILES CN(C)c1nc2n(ccc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H18N4O5/c1-16(2)13-14-10-6(11(21)15-13)3-4-17(10)12-9(20)8(19)7(5-18)22-12/h3-4,7-9,12,18-20H,5H2,1-2H3,(H,14,15,21)/t7-,8-,9-,12?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165135 (CHEMBL193790 | disodium 2-amino-9-[(2R,4S,5R)-5-[(...) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NC(C([O-])=O)C(=O)c2ccccc2)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C25H33N6O10P/c1-12(2)39-19-15(10-38-42(36,37)30-16(24(34)35)18(32)14-8-6-5-7-9-14)41-23(20(19)40-13(3)4)31-11-27-17-21(31)28-25(26)29-22(17)33/h5-9,11-13,15-16,19-20,23H,10H2,1-4H3,(H,34,35)(H2,30,36,37)(H3,26,28,29,33)/p-1/t15-,16?,19+,20?,23-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370489 (CHEMBL607902) Show SMILES CN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=S)c12 |r| Show InChI InChI=1S/C11H17N5O4S/c1-15-3-16(8-5(15)9(21)14-11(12)13-8)10-7(19)6(18)4(2-17)20-10/h4,6-7,10,17-19H,2-3H2,1H3,(H3,12,13,14,21)/t4-,6-,7-,10?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165142 (CHEMBL194978 | disodium 2-amino-9-[(2R,4S,5R)-5-[(...) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C18H29N6O9P/c1-8(2)31-13-10(6-30-34(28,29)21-5-11(25)26)33-17(14(13)32-9(3)4)24-7-20-12-15(24)22-18(19)23-16(12)27/h7-10,13-14,17H,5-6H2,1-4H3,(H,25,26)(H2,21,28,29)(H3,19,22,23,27)/p-1/t10-,13+,14?,17-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50165141 (CHEMBL436762 | disodium 2-amino-9-[(2R,4S,5R)-5-{[...) Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NC(Cc2c[nH]c3ccccc23)C([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O Show InChI InChI=1S/C27H36N7O9P/c1-13(2)41-21-19(43-25(22(21)42-14(3)4)34-12-30-20-23(34)31-27(28)32-24(20)35)11-40-44(38,39)33-18(26(36)37)9-15-10-29-17-8-6-5-7-16(15)17/h5-8,10,12-14,18-19,21-22,25,29H,9,11H2,1-4H3,(H,36,37)(H2,33,38,39)(H3,28,31,32,35)/p-1/t18?,19-,21+,22?,25-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50370493 (CHEMBL609636) Show SMILES CNc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10?/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Homo sapiens (Human))	BDBM50410169 (CHEMBL2021409) Show SMILES COC(=O)C(Cc1ccccc1)NP([O-])(=O)OC[C@H]1O[C@H]([C@H](OC(C)C)[C@@H]1OC(C)C)n1cnc2c1nc(N)[nH]c2=O Show InChI InChI=1S/C26H37N6O9P/c1-14(2)39-20-18(12-38-42(35,36)31-17(25(34)37-5)11-16-9-7-6-8-10-16)41-24(21(20)40-15(3)4)32-13-28-19-22(32)29-26(27)30-23(19)33/h6-10,13-15,17-18,20-21,24H,11-12H2,1-5H3,(H2,31,35,36)(H3,27,29,30,33)/p-1/t17?,18-,20-,21-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50079401 (CHEMBL62381 | Sodium butyrate | Sodium; butyrate |...) Show SMILES CCCC([O-])=O Show InChI InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50003616 (2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...) Show SMILES CCCC(CCC)C(O)=O Show InChI InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50079401 (CHEMBL62381 | Sodium butyrate | Sodium; butyrate |...) Show SMILES CCCC([O-])=O Show InChI InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Tissue factor (Homo sapiens (Human))	BDBM50003616 (2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...) Show SMILES CCCC(CCC)C(O)=O Show InChI InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotti...				J Biol Chem 282: 28408-18 (2007) Article DOI: 10.1074/jbc.M703586200 BindingDB Entry DOI: 10.7270/Q2RJ4KCF
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316307 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-chlorobenzyl)-6-oxo...) Show SMILES Nc1nc2n(c[n+](Cc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H19ClN5O8P/c18-9-3-1-8(2-4-9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.99E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316308 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-chlorobenzyl)-6-oxo...) Show SMILES Nc1nc2n(c[n+](Cc3cccc(Cl)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H19ClN5O8P/c18-9-3-1-2-8(4-9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316309 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-chlorobenzyl)-6-oxo...) Show SMILES Nc1nc2n(c[n+](Cc3ccccc3Cl)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H19ClN5O8P/c18-9-4-2-1-3-8(9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316310 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-chloro-5-fluorobenz...) Show SMILES Nc1nc2n(c[n+](Cc3cc(F)ccc3Cl)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H18ClFN5O8P/c18-9-2-1-8(19)3-7(9)4-23-6-24(14-11(23)15(27)22-17(20)21-14)16-13(26)12(25)10(32-16)5-31-33(28,29)30/h1-3,6,10,12-13,16,25-26H,4-5H2,(H4-,20,21,22,27,28,29,30)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316311 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-fluorobenzyl)-6-oxo...) Show SMILES Nc1nc2n(c[n+](Cc3ccccc3F)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C17H19FN5O8P/c18-9-4-2-1-3-8(9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316312 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-carboxybenzyl)-6-ox...) Show SMILES Nc1nc2n(c[n+](Cc3ccc(cc3)C(O)=O)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C18H20N5O10P/c19-18-20-14-11(15(26)21-18)22(5-8-1-3-9(4-2-8)17(27)28)7-23(14)16-13(25)12(24)10(33-16)6-32-34(29,30)31/h1-4,7,10,12-13,16,24-25H,5-6H2,(H5-,19,20,21,26,27,28,29,30,31)/t10-,12-,13-,16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.59E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316313 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-methoxybenzyl)-6-ox...) Show SMILES COc1cccc(C[n+]2cn([C@@H]3O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]3O)c3nc(N)[nH]c(=O)c23)c1 |r| Show InChI InChI=1S/C18H22N5O9P/c1-30-10-4-2-3-9(5-10)6-22-8-23(15-12(22)16(26)21-18(19)20-15)17-14(25)13(24)11(32-17)7-31-33(27,28)29/h2-5,8,11,13-14,17,24-25H,6-7H2,1H3,(H4-,19,20,21,26,27,28,29)/t11-,13-,14-,17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
					More data for this Ligand-Target Pair

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