Reaction Details |
| Report a problem with these data |
Target | Eukaryotic translation initiation factor 4E |
---|
Ligand | BDBM50165134 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_305877 (CHEMBL831921) |
---|
IC50 | >400000±n/a nM |
---|
Citation | Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg Med Chem Lett15:2177-80 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Eukaryotic translation initiation factor 4E |
---|
Name: | Eukaryotic translation initiation factor 4E |
Synonyms: | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN |
Type: | Protein |
Mol. Mass.: | 25095.44 |
Organism: | Homo sapiens (Human) |
Description: | P06730 |
Residue: | 217 |
Sequence: | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
|
|
|
BDBM50165134 |
---|
n/a |
---|
Name | BDBM50165134 |
Synonyms: | 2-Amino-7-ethyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium | CHEMBL193326 |
Type | Small organic molecule |
Emp. Form. | C18H30N5O5 |
Mol. Mass. | 396.4608 |
SMILES | CC[n+]1cn([C@@H]2O[C@H](CO)[C@H](OC(C)C)C2OC(C)C)c2nc(N)[nH]c(=O)c12 |
Structure |
|