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TargetSerine protease 1/Trypsin-2
LigandBDBM50157339
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302282 (CHEMBL830300)
Ki 13600±n/a nM
Citation Ueno, HYokota, KHoshi, JYasue, KHayashi, MHase, YUchida, IAisaka, KKatoh, SCho, H Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. J Med Chem48:3586-604 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine protease 1/Trypsin-2
Name:Serine protease 1/Trypsin-2
Synonyms:Trypsin II
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 212335
Components:This complex has 2 components.
Component 1
Name:Serine protease 1
Synonyms:Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:Enzyme
Mol. Mass.:26557.80
Organism:Homo sapiens (Human)
Description:P07477
Residue:247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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Component 2
Name:Trypsin-2
Synonyms:Anionic trypsinogen | PRSS2 | Serine protease 2 | TRY2 | TRY2_HUMAN | TRYP2 | Thrombin & trypsin | Trypsin | Trypsin II | Trypsin-2
Type:PROTEIN
Mol. Mass.:26479.43
Organism:Homo sapiens (Human)
Description:ChEMBL_41517
Residue:247
Sequence:
MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN
SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT
NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK
DTIAANS
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BDBM50157339
n/a
NameBDBM50157339
Synonyms:4-(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxymethyl)-1-pyrimidin-4-yl-piperidine-4-carboxylic acid; dihydrochloride | CHEMBL195428 | CHEMBL534707
TypeSmall organic molecule
Emp. Form.C21H26N6O3
Mol. Mass.410.4695
SMILESNC(=N)N1CCc2ccc(OCC3(CCN(CC3)c3ccncn3)C(O)=O)cc2C1
Structure
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