| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocyte-stimulating hormone receptor |
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| Ligand | BDBM50163145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306266 (CHEMBL828399) |
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| IC50 | 0.300000±n/a nM |
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| Citation |  Cai, M; Mayorov, AV; Cabello, C; Stankova, M; Trivedi, D; Hruby, VJ Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. J Med Chem48:1839-48 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocyte-stimulating hormone receptor |
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| Name: | Melanocyte-stimulating hormone receptor |
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| Synonyms: | MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 34717.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01726 |
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| Residue: | 317 |
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| Sequence: | MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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| BDBM50163145 |
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| n/a |
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| Name | BDBM50163145 |
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| Synonyms: | CHEMBL413439 | H-Tyr-Val-Nle-Gly-His-D-Nal(2'')-Arg-D-Trp-Asp-Arg-Phe-Gly-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C79H103N21O16 |
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| Mol. Mass. | 1602.7942 |
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| SMILES | CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O |
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| Structure | 
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