Reaction Details |
| Report a problem with these data |
Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Ligand | BDBM50163568 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_303177 (CHEMBL829671) |
---|
Ki | 0.36±n/a nM |
---|
Citation | Jiang, W; Guan, J; Macielag, MJ; Zhang, S; Qiu, Y; Kraft, P; Bhattacharjee, S; John, TM; Haynes-Johnson, D; Lundeen, S; Sui, Z Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction. J Med Chem48:2126-33 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cGMP-specific 3',5'-cyclic phosphodiesterase |
---|
Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
Synonyms: | PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A |
Type: | PROTEIN |
Mol. Mass.: | 94547.60 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_155367 |
Residue: | 833 |
Sequence: | MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKIS
ASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSH
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIR
LEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREH
DANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKN
KVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
TLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTA
CDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFID
AICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
|
|
|
BDBM50163568 |
---|
n/a |
---|
Name | BDBM50163568 |
Synonyms: | 3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-3-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one | CHEMBL178541 |
Type | Small organic molecule |
Emp. Form. | C28H21N5O2 |
Mol. Mass. | 459.4986 |
SMILES | Oc1c2CN(C(c2nc2ccccc12)c1ccc2OCCc2c1)c1ncc(cn1)-c1cccnc1 |
Structure |
|