| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50173715 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320794 (CHEMBL884749) |
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| Ki | 2100±n/a nM |
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| Citation |  Mattson, RJ; Catt, JD; Denhart, DJ; Deskus, JA; Ditta, JL; Higgins, MA; Marcin, LR; Sloan, CP; Beno, BR; Gao, Q; Cunningham, MA; Mattson, GK; Molski, TF; Taber, MT; Lodge, NJ Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J Med Chem48:6023-34 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68497.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01959 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50173715 |
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| n/a |
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| Name | BDBM50173715 |
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| Synonyms: | (+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-indole-5-carbonitrile | 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-1H-indole-5-carbonitrile | 3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-indole-5-carbonitrile | CHEMBL196468 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3 |
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| Mol. Mass. | 239.3156 |
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| SMILES | CN(C)C[C@H]1C[C@@H]1c1c[nH]c2ccc(cc12)C#N |
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| Structure | 
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