Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50273571 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_420086 (CHEMBL855347) |
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IC50 | 250±n/a nM |
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Citation | Jung, FH; Pasquet, G; Lambert-van der Brempt, C; Lohmann, JJ; Warin, N; Renaud, F; Germain, H; De Savi, C; Roberts, N; Johnson, T; Dousson, C; Hill, GB; Mortlock, AA; Heron, N; Wilkinson, RW; Wedge, SR; Heaton, SP; Odedra, R; Keen, NJ; Green, S; Brown, E; Thompson, K; Brightwell, S Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem49:955-70 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50273571 |
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n/a |
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Name | BDBM50273571 |
Synonyms: | CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide | TCMDC-135395 |
Type | Small organic molecule |
Emp. Form. | C29H32N4O3S |
Mol. Mass. | 516.654 |
SMILES | CCS(=O)(=O)Nc1ccc2NC(=O)C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)c2c1 |w:15.15| |
Structure |
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