| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM50181844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_332071 (CHEMBL859603) |
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| Ki | 0.183000±n/a nM |
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| Citation |  Becker, DP; Flynn, DL; Moormann, AE; Nosal, R; Villamil, CI; Loeffler, R; Gullikson, GW; Moummi, C; Yang, DC Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists. J Med Chem49:1125-39 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43735.29 |
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| Organism: | GUINEA PIG |
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| Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
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| Residue: | 388 |
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| Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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| BDBM50181844 |
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| n/a |
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| Name | BDBM50181844 |
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| Synonyms: | (1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amino-5-chloro-2-methoxybenzoate | CHEMBL201621 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21ClN2O3 |
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| Mol. Mass. | 324.803 |
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| SMILES | COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12 |
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| Structure | 
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