Reaction Details |
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Target | Glycogen phosphorylase, muscle form |
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Ligand | BDBM50184615 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_365330 (CHEMBL871240) |
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IC50 | 3300±n/a nM |
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Citation | Chen, J; Liu, J; Zhang, L; Wu, G; Hua, W; Wu, X; Sun, H Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase. Bioorg Med Chem Lett16:2915-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, muscle form |
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Name: | Glycogen phosphorylase, muscle form |
Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
Type: | Enzyme |
Mol. Mass.: | 97296.32 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
Residue: | 843 |
Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM50184615 |
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n/a |
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Name | BDBM50184615 |
Synonyms: | (4aS,6aS,6bR,10S,12aR,14bS,E)-10-(3-(4-chlorophenyl)acryloyloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | CHEMBL150213 |
Type | Small organic molecule |
Emp. Form. | C39H53ClO4 |
Mol. Mass. | 621.289 |
SMILES | CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](OC(=O)\C=C\c6ccc(Cl)cc6)C(C)(C)C5CC[C@@]34C)[C@@H]2C1)C(O)=O |c:10| |
Structure |
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