| Reaction Details |
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 | Report a problem with these data |
| Target | Orotidine 5'-phosphate decarboxylase |
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| Ligand | BDBM21340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_381849 (CHEMBL869171) |
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| Ki | 12400±n/a nM |
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| Citation |  Poduch, E; Bello, AM; Tang, S; Fujihashi, M; Pai, EF; Kotra, LP Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem49:4937-45 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orotidine 5'-phosphate decarboxylase |
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| Name: | Orotidine 5'-phosphate decarboxylase |
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| Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF |
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| Type: | Enzyme |
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| Mol. Mass.: | 24909.45 |
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| Organism: | Methanobacterium thermoautotrophicum |
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| Description: | n/a |
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| Residue: | 228 |
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| Sequence: | MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
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| BDBM21340 |
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| n/a |
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| Name | BDBM21340 |
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| Synonyms: | 6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C8H12N3O9P |
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| Mol. Mass. | 325.1693 |
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| SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O |r| |
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| Structure | 
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