| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM50192077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_404507 (CHEMBL910890) |
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| IC50 | 11±n/a nM |
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| Citation |  Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure. Bioorg Med Chem Lett16:5122-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM50192077 |
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| n/a |
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| Name | BDBM50192077 |
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| Synonyms: | 23-hydroxy-16-oxa-8-thia-9,22,24-triazapentacyclo[15.6.2.1^{6,9}.0^{2,7}.0^{21,25}]hexacosa-1(24),2(7),3,5,17(25),18,20,22-octaen-26-one | CHEMBL424722 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O3S |
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| Mol. Mass. | 393.459 |
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| SMILES | O=c1n2CCCCCCOc3cccc4[nH]c(=O)c(nc34)-c3cccc1c3s2 |
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| Structure | 
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