Reaction Details |
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Target | Cyclin-dependent kinase 4 |
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Ligand | BDBM50192080 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_404507 (CHEMBL910890) |
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IC50 | 13±n/a nM |
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Citation | Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure. Bioorg Med Chem Lett16:5122-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 4 |
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Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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BDBM50192080 |
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n/a |
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Name | BDBM50192080 |
Synonyms: | 9-methyl-8,9,10,11-tetrahydro-7H-16,18-(epiminomethano)-4,6-methanodibenzo[i,m][1,8,4,7,12]oxathiatriazacyclotetradecine-19,21-dione | CHEMBL1189501 |
Type | Small organic molecule |
Emp. Form. | C20H19N5O3 |
Mol. Mass. | 377.3966 |
SMILES | CN1CCOc2cccc3nc(O)c(nc23)-c2cccc3c(O)n(CC1)nc23 |
Structure |
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