| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50200336 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_410401 (CHEMBL911221) |
|---|
| IC50 | 4.5±n/a nM |
|---|
| Citation |  Camps, P; Gómez, E; Muñoz-Torrero, D; Badia, A; Clos, MV; Curutchet, C; Muñoz-Muriedas, J; Luque, FJ Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. J Med Chem49:6833-40 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_BOVIN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67659.62 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 613 |
|---|
| Sequence: | MRPPWCPLHTPSLTPPLLLLLFLIGGGAEAEGPEDPELLVMVRGGRLRGLRLMAPRGPVS
AFLGIPFAEPPVGPRRFLPPEPKRPWPGVLNATAFQSVCYQYVDTLYPGFEGTEMWNPNR
ELSEDCLYLNVWTPYPRPSSPTPVLVWIYGGGFYSGASSLDVYDGRFLTQAEGTVLVSMN
YRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVG
MHLLSPPSRGLFHRAVLQSGAPNGPWATVGVGEARRRATLLARLVGCPPGGAGGNDTELV
ACLRARPAQDLVDHEWRVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGV
VKDEGSYFLVYGAPGFSKDNESLISRAQFLAGVRVGVPQASDLAAEAVVLHYTDWLHPED
PARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLSWPLWMGVPHGYE
IEFIFGLPLEPSLNYTIEERTFAQRLMRYWANFARTGDPNDPRDPKAPQWPPYTAGAQQY
VSLNLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQ
FDHYSKQDRCSDL
|
|
|
|---|
| BDBM50200336 |
|---|
| n/a |
|---|
| Name | BDBM50200336 |
|---|
| Synonyms: | (-)-(7S,11S)-huprine H5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N2 |
|---|
| Mol. Mass. | 279.3988 |
|---|
| SMILES | CCC1=C[C@H]2C[C@@H](C1)c1c(C2)[nH+]c2cc(C)ccc2c1N |t:2| |
|---|
| Structure | 
|
|---|
Search and Browse
