| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Ligand | BDBM50194430 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_424366 (CHEMBL911297) |
|---|
| IC50 | 12100±n/a nM |
|---|
| Citation |  Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett16:5605-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
|---|
| Synonyms: | EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 44640.67 |
|---|
| Organism: | Pseudomonas aeruginosa (G-proteobacteria) |
|---|
| Description: | P. aeruginosa MurA |
|---|
| Residue: | 421 |
|---|
| Sequence: | MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM
GVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIG
SRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALAN
GRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGT
YLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTA
PYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGV
PKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVP
G
|
|
|
|---|
| BDBM50194430 |
|---|
| n/a |
|---|
| Name | BDBM50194430 |
|---|
| Synonyms: | CHEMBL374146 | CYNAROPICRIN |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22O6 |
|---|
| Mol. Mass. | 346.3744 |
|---|
| SMILES | OCC(=C)C(=O)O[C@H]1CC(=C)[C@@H]2C[C@H](O)C(=C)[C@@H]2[C@H]2OC(=O)C(=C)[C@H]12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
