| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
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| Ligand | BDBM50195166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_424815 (CHEMBL909059) |
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| IC50 | >30000±n/a nM |
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| Citation |  Zhao, Z; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Wolkenberg, SE; Lindsley, CW Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorg Med Chem Lett16:5968-72 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 2 |
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| Name: | Sodium- and chloride-dependent glycine transporter 2 |
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| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87438.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
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| Residue: | 797 |
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| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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| BDBM50195166 |
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| n/a |
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| Name | BDBM50195166 |
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| Synonyms: | 3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide | CHEMBL222720 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28ClF2N3O5S |
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| Mol. Mass. | 507.979 |
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| SMILES | CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(CC1)C(=O)N1CCOCC1 |
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| Structure | 
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