Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 1 |
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Ligand | BDBM50195169 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424804 (CHEMBL909053) |
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IC50 | 7.6±n/a nM |
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Citation | Zhao, Z; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Wolkenberg, SE; Lindsley, CW Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides. Bioorg Med Chem Lett16:5968-72 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 1 |
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Name: | Sodium- and chloride-dependent glycine transporter 1 |
Synonyms: | GlyT-1 | Glyt1 | SC6A9_MOUSE | Slc6a9 | Solute carrier family 6 member 9 |
Type: | PROTEIN |
Mol. Mass.: | 76552.86 |
Organism: | Mus musculus |
Description: | ChEMBL_1351579 |
Residue: | 692 |
Sequence: | MIGGDTRAASAHPGMASAQGPVATPSPEQPFPGTTSVSLARPVLRVWHGAHSSGLLPNLI
AQHSPAMAQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNG
GGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGI
YYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHL
FNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGK
VVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC
AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD
HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWIL
QKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHR
NYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGF
LMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSP
EDGFEVQPLHPDKAQIPIVGSNGSSRFQDSRI
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BDBM50195169 |
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n/a |
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Name | BDBM50195169 |
Synonyms: | 2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide | CHEMBL376472 |
Type | Small organic molecule |
Emp. Form. | C21H29Cl2N3O5S |
Mol. Mass. | 506.443 |
SMILES | CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 |
Structure |
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