Reaction Details |
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Target | Adenosine receptor A1 |
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Ligand | BDBM50156651 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_429601 (CHEMBL919033) |
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Ki | >500±n/a nM |
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Citation | Peng, H; Kumaravel, G; Yao, G; Sha, L; Wang, J; Van Vlijmen, H; Bohnert, T; Huang, C; Vu, CB; Ensinger, CL; Chang, H; Engber, TM; Whalley, ET; Petter, RC Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists. J Med Chem47:6218-29 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine receptor A1 |
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Name: | Adenosine receptor A1 |
Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
Type: | Protein |
Mol. Mass.: | 36704.13 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 326 |
Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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BDBM50156651 |
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n/a |
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Name | BDBM50156651 |
Synonyms: | (7RS,9aRS)-N5-[2-(2,4-difluorobenzyl)octahydropyrido-[1,2-a]pyrazin-7-ylmethyl]-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine | CHEMBL222901 |
Type | Small organic molecule |
Emp. Form. | C24H27F2N9O |
Mol. Mass. | 495.5277 |
SMILES | Nc1nc(NC[C@@H]2CC[C@@H]3CN(Cc4ccc(F)cc4F)CCN3C2)nc2nc(nn12)-c1ccco1 |r| |
Structure |
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