| Reaction Details |
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 | Report a problem with these data |
| Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Ligand | BDBM31768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430506 (CHEMBL917755) |
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| IC50 | 312±n/a nM |
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| Citation |  Kahraman, M; Sinishtaj, S; Dolan, PM; Kensler, TW; Peleg, S; Saha, U; Chuang, SS; Bernstein, G; Korczak, B; Posner, GH Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3). J Med Chem47:6854-63 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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| Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
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| Type: | Protein |
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| Mol. Mass.: | 58889.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07973 |
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| Residue: | 514 |
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| Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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| BDBM31768 |
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| n/a |
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| Name | BDBM31768 |
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| Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28Cl2N4O4 |
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| Mol. Mass. | 531.431 |
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| SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
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| Structure | 
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